HIV-1 Drug Resistance Profiles in Children and Adults With Viral Load of [less than]50 Copies/mL Receiving Combination Therapy

Article Abstract:

HIV may still continue to reproduce when AIDS patients take highly active antiretroviral therapy (HAART), but this does not necessarily mean the virus has become resistant to the drugs. Any drug-resistance mutations found could be mutations that developed prior to HAART treatment.

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Intermittent HIV-1 viremia (blips) and drug resistance in patients receiving HAART

Article Abstract:

A hypothesis to test whether blips represent random biological and statistical variation around mean steady-state HIV-1 RNA levels slightly below 50 copies/mL rather than biologically significant elevations in viremia is presented. It is concluded that most blips appear to represent random biological and statistical variation around mean HIV-1 levels below 50 copies/mL rather than clinically significant elevations in viremia.

United States, Science & research, Causes of, Dosage and administration, AIDS (Disease), Drug resistance, AIDS research, Highly active antiretroviral therapy

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Antiretroviral Drug Resistance Testing in Adults With HIV Infection, Part 2

Article Abstract:

Genetic testing of the virus in HIV-infected patients may be useful in guiding antiviral drug therapy to maximize effectiveness and reduce development of drug resistance. A panel of experts assembled by the International AIDS Society - USA recommends viral load and CD4+ T-cell count as immunologic guides for antiretroviral drug therapy. Poor patient compliance with treatment protocols contributes to the development of drug-resistant HIV. Resistance testing may be useful for determining the optimal drugs for use in treatment.

Reports, Prevention, Physiological aspects, Genetic aspects, Antiviral agents, International AIDS Society

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